GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs13191362 | 1 | rs4260737 | chr6:163137746 | PACRG | chr6:163148164-163736523:+ | 0.54 | 7.47 | 3.95E-13 | Body mass index |
| THCA | cis | rs6496667 | 1 | rs4261510 | chr15:90890606 | IQGAP1 | chr15:90931473-91045475:+ | 0.15 | 4.63 | 4.67E-6 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs4261510 | chr15:90890606 | TTLL13 | chr15:90792764-90815443:+ | 0.3 | 5.15 | 3.83E-7 | Rheumatoid arthritis |
| THCA | cis | rs6805251 | 1 | rs4261913 | chr3:119546197 | GSK3B | chr3:119540804-119813264:- | -0.14 | -4.9 | 1.32E-6 | HDL cholesterol |
| THCA | cis | rs4263408 | 1 | rs4263408 | chr4:39785276 | RPL9 | chr4:39455747-39460568:- | -0.43 | -7.98 | 1.08E-14 | Plasma amyloid beta peptide concentrations (ABx-40) |
| THCA | cis | rs4263408 | 1 | rs4263408 | chr4:39785276 | UBE2K | chr4:39699664-39784408:+ | -0.16 | -3.92 | 0.000102 | Plasma amyloid beta peptide concentrations (ABx-40) |
| THCA | cis | rs42648 | 1 | rs42648 | chr7:89977760 | GTPBP10 | chr7:89969690-90016650:+ | 0.19 | 4.86 | 1.61E-6 | Homocysteine levels |
| THCA | cis | rs42648 | 1 | rs42649 | chr7:89977789 | GTPBP10 | chr7:89969690-90016650:+ | 0.19 | 4.78 | 2.32E-6 | Homocysteine levels |
| THCA | cis | rs6982751 | 1 | rs4265148 | chr8:10816503 | CTSB | chr8:11700036-11725646:- | 0.22 | 3.47 | 0.000575 | Asthma and hay fever |
| THCA | cis | rs42648 | 1 | rs42656 | chr7:89981636 | GTPBP10 | chr7:89969690-90016650:+ | 0.2 | 4.99 | 8.62E-7 | Homocysteine levels |
| THCA | cis | rs4265793 | 1 | rs4265793 | chr16:19028549 | COQ7 | chr16:19078927-19091350:+ | -0.29 | -3.76 | 0.000188 | Response to angiotensin II receptor blocker therapy |
| THCA | cis | rs42648 | 1 | rs42658 | chr7:89981915 | GTPBP10 | chr7:89969690-90016650:+ | 0.18 | 4.75 | 2.74E-6 | Homocysteine levels |
| THCA | cis | rs9473555 | 1 | rs4267943 | chr6:49439805 | CENPQ | chr6:49431096-49460820:+ | 0.24 | 5.02 | 7.46E-7 | Folate pathway vitamin levels |
| THCA | cis | rs9473555 | 1 | rs4267943 | chr6:49439805 | MUT | chr6:49398994-49431031:- | -0.28 | -9.42 | 1.93E-19 | Folate pathway vitamin levels |
| THCA | cis | rs4332428 | 1 | rs4268415 | chr10:4983590 | AKR1C2 | chr10:4964715-5060207:- | 0.27 | 3.72 | 0.000226 | Height |